Primary Purpose
| primary_purpose | Study_Count |
|---|---|
| Treatment | 57 |
| Health Services Research | 7 |
| Diagnostic | 6 |
| Prevention | 5 |
| Supportive Care | 5 |
| Screening | 4 |
| Other | 3 |
| NA | 3 |
| Basic Science | 2 |
| Device Feasibility | 2 |
Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD
See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG
To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html
| Type | Study_count |
|---|---|
| Total_Studies | 166 |
| interventional | 94 |
| Observational | 70 |
| Registry | 2 |
```
| intervention_type | Study_Count |
|---|---|
| Behavioral | 21 |
| Other | 18 |
| Drug | 12 |
| Device | 11 |
| Drug|placebo | 10 |
| Procedure | 5 |
| Diagnostic Test | 3 |
| Dietary Supplement|placebo | 2 |
| Drug|Other | 2 |
| Behavioral|Device | 1 |
| Behavioral|Dietary Supplement|Other | 1 |
| Biological|Device | 1 |
| Biological|Drug | 1 |
| Biological|placebo | 1 |
| Combination Product | 1 |
| Device|Drug|Procedure | 1 |
| Device|placebo | 1 |
| Dietary Supplement | 1 |
| Other|Procedure | 1 |
| Country | Study_Count |
|---|---|
| United States | 47 |
| France | 8 |
| Spain | 5 |
| NA | 4 |
| Brazil | 3 |
| United Kingdom | 3 |
| Canada | 2 |
| Greece | 2 |
| Japan | 2 |
| Turkey | 2 |
| Belgium | 1 |
| Canada|United States|Australia|Netherlands|New Zealand|Puerto Rico|Switzerland | 1 |
| China | 1 |
| Cyprus | 1 |
| Denmark | 1 |
| Egypt | 1 |
| Hong Kong|Japan|Malaysia|Singapore|Taiwan | 1 |
| Netherlands | 1 |
| Taiwan | 1 |
| Thailand | 1 |
| United States|Argentina|Canada|France|Italy|Mexico|New Zealand|Singapore|Spain|United Kingdom | 1 |
| United States|Australia|Canada|Ireland|New Zealand|Puerto Rico|Switzerland | 1 |
| United States|Australia|Canada|New Zealand|Puerto Rico | 1 |
| United States|Australia|Canada|New Zealand|Puerto Rico|Saudi Arabia | 1 |
| United States|Brazil | 1 |
| United States|United Kingdom | 1 |
| Site_count | Study_Count |
|---|---|
| 1 | 71 |
| 2 | 8 |
| 3 | 3 |
| 4 | 1 |
| 5 | 1 |
| 6 | 1 |
| 9 | 2 |
| 10 | 1 |
| 31 | 1 |
| 37 | 1 |
| 185 | 1 |
| 211 | 1 |
| 237 | 1 |
| 244 | 1 |
| Phase | Study_Count |
|---|---|
| N/A | 66 |
| Phase 2 | 12 |
| Phase 1 | 6 |
| Phase 3 | 6 |
| Phase 1/Phase 2 | 2 |
| Phase 2/Phase 3 | 1 |
| Phase 4 | 1 |
| Number_of_Arms | Count_of_Studies |
|---|---|
| 1 | 27 |
| 2 | 45 |
| 3 | 10 |
| 4 | 5 |
| 6 | 1 |
| 7 | 1 |
| 8 | 1 |
| NA | 4 |
| Measure | N.A | Phase.1 | Phase.1.Phase.2 | Phase.2 | Phase.2.Phase.3 | Phase.3 | Phase.4 |
|---|---|---|---|---|---|---|---|
| Min. | 5.0000 | 12.0000 | 15.00 | 23.00000 | 120 | 175.000 | 42 |
| 1st Qu. | 17.0000 | 13.7500 | 21.75 | 34.75000 | 120 | 254.500 | 42 |
| Median | 40.0000 | 25.5000 | 28.50 | 73.50000 | 120 | 302.500 | 42 |
| Mean | 167.4615 | 111.8333 | 28.50 | 88.16667 | 120 | 2850.667 | 42 |
| 3rd Qu. | 80.0000 | 121.2500 | 35.25 | 127.50000 | 120 | 5127.250 | 42 |
| Max. | 3819.0000 | 445.0000 | 42.00 | 200.00000 | 120 | 9350.000 | 42 |
| group_type | Group_Count |
|---|---|
| Experimental | 97 |
| Active Comparator | 33 |
| Other | 23 |
| Placebo Comparator | 21 |
| No Intervention | 13 |
| NA | 4 |
| Sham Comparator | 1 |
| intervention_model | Study_Count |
|---|---|
| Parallel Assignment | 52 |
| Single Group Assignment | 31 |
| Crossover Assignment | 10 |
| Sequential Assignment | 1 |
| primary_purpose | Study_Count |
|---|---|
| Treatment | 57 |
| Health Services Research | 7 |
| Diagnostic | 6 |
| Prevention | 5 |
| Supportive Care | 5 |
| Screening | 4 |
| Other | 3 |
| NA | 3 |
| Basic Science | 2 |
| Device Feasibility | 2 |
| Country | Study_Count |
|---|---|
| United States | 30 |
| France | 7 |
| NA | 4 |
| Brazil | 3 |
| United States|Canada | 3 |
| Croatia | 2 |
| Spain | 2 |
| Australia|Belgium|Canada|Portugal|Spain|United Kingdom | 1 |
| France|United States|Spain | 1 |
| Germany | 1 |
| Italy | 1 |
| Japan | 1 |
| Mexico | 1 |
| Saudi Arabia | 1 |
| Turkey | 1 |
| United Kingdom | 1 |
| United States|Argentina|Australia|Canada|Czech Republic|Hungary|Ireland|Israel|Italy|Spain | 1 |
| United States|Argentina|Canada|France|Italy|Spain|United Kingdom | 1 |
| United States|Argentina|Canada|Mexico|New Zealand|Singapore|Spain | 1 |
| United States|Australia|Canada|Puerto Rico | 1 |
| United States|Belgium|Canada|Italy|Netherlands|Sweden | 1 |
| United States|Canada|Ireland|Italy|Korea, Republic of|Spain | 1 |
| United States|Canada|Italy | 1 |
| United States|France | 1 |
| United States|India|Malaysia | 1 |
| United States|Spain|Taiwan | 1 |
| Site_count | Study_Count |
|---|---|
| 1 | 32 |
| 2 | 7 |
| 3 | 3 |
| 4 | 1 |
| 6 | 3 |
| 7 | 3 |
| 8 | 2 |
| 9 | 1 |
| 10 | 3 |
| 12 | 2 |
| 14 | 1 |
| 16 | 1 |
| 22 | 1 |
| 25 | 1 |
| 26 | 1 |
| 27 | 2 |
| 29 | 2 |
| 35 | 2 |
| 36 | 1 |
| 189 | 1 |
| Measure | Observational |
|---|---|
| Min | 1.000 |
| 1st Qu | 73.000 |
| Median | 260.000 |
| Mean | 3267.536 |
| 3rd Qu | 2000.000 |
| Max | 100000.000 |
| observational_model | Study_Count |
|---|---|
| Cohort | 31 |
| Case-Only | 11 |
| Case-Control | 10 |
| Case Control | 6 |
| NA | 5 |
| Family-Based | 3 |
| Other | 3 |
| Case-Crossover | 1 |
| time_perspective | Study_Count |
|---|---|
| Prospective | 46 |
| Cross-Sectional | 18 |
| Retrospective | 5 |
| NA | 1 |
| Country | Study_Count |
|---|---|
| United States | 1 |
| United States|Australia|Ireland|Spain|Sweden|United Kingdom | 1 |
| Site_count | Study_Count |
|---|---|
| 1 | 1 |
| 21 | 1 |
| Measure | Registries |
|---|---|
| Min | 800 |
| 1st Qu | 5840 |
| Median | 10880 |
| Mean | 10880 |
| 3rd Qu | 15920 |
| Max | 20960 |
| observational_model | Study_Count |
|---|---|
| Case-Control | 1 |
| Cohort | 1 |
| time_perspective | Study_Count |
|---|---|
| Prospective | 2 |
| target_duration | Study_Count |
|---|---|
| 2 Years | 1 |
| 25 Years | 1 |
#If less then 500 trials
| nct_id | brief_title | link | overall_status | source | primary_completion_date |
|---|---|---|---|---|---|
| NCT03914625 | A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia | https://ClinicalTrials.gov/show/NCT03914625 | Recruiting | National Cancer Institute (NCI) | 2027-06-30 |
| NCT03367793 | Spectacles for Patients With Down Syndrome | https://ClinicalTrials.gov/show/NCT03367793 | Completed | University of Houston | 2019-06-10 |
| NCT03267602 | Role of Sleep Apnea in the Neuropsychological Function in Down Syndrome People | https://ClinicalTrials.gov/show/NCT03267602 | Completed | National Taiwan University Hospital | 2016-12-31 |
| NCT03210675 | Early Detection and Treatment of Respiratory Sleep Disorders in Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT03210675 | Active, not recruiting | Institut Jerome Lejeune | 2022-12-31 |
| NCT03206957 | Correlation Between Optic Nerve Vessel Anomalies, Serum Angiogenic Factors and Renal Anomalies in Down Syndrome Children | https://ClinicalTrials.gov/show/NCT03206957 | Recruiting | Queen Fabiola Children’s University Hospital | 2019-06-01 |
| NCT03200041 | Clinical Evaluation of the IONA Test for Non-invasive Pre Natal Screening in Twin Pregnancies | https://ClinicalTrials.gov/show/NCT03200041 | Completed | Premaitha Health | 2019-12-31 |
| NCT03192540 | The Impact of an 8-week Supported Exercise Program on Fitness and Symptoms in Adolescents With Down Syndrome | https://ClinicalTrials.gov/show/NCT03192540 | Active, not recruiting | Boston Children’s Hospital | 2019-01-12 |
| NCT03135236 | Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome | https://ClinicalTrials.gov/show/NCT03135236 | Completed | Advocate Health Care | 2017-09-30 |
| NCT03126734 | Effects of Infant Massage on Acceptance, Commitment and Conscience of Influence of Parents With Down Syndrome Babies | https://ClinicalTrials.gov/show/NCT03126734 | Completed | University of Seville | 2017-03-15 |
| NCT03084497 | Effects of Infant Massage on Development of Down Syndrome Babies | https://ClinicalTrials.gov/show/NCT03084497 | Completed | University of Seville | 2016-09-30 |
| NCT03058640 | Effects of Karate in Adolescents With Down Syndrome | https://ClinicalTrials.gov/show/NCT03058640 | Completed | University of Michigan | 2019-03-31 |
| NCT02996175 | Treatment of Sleep Disturbances in School-age Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT02996175 | Completed | Children’s Hospital Medical Center, Cincinnati | 2018-05-31 |
| NCT02971254 | The Effects of Inhalational Anaesthetics in Cognitive Functions in Down Syndrome Patients | https://ClinicalTrials.gov/show/NCT02971254 | Completed | Asklepieion Voulas General Hospital | 2019-01-06 |
| NCT02938988 | Antimicrobial Photodynamic Therapy as an Adjunct Treatment for Periodontal Disease in Down’s Syndrome Patients | https://ClinicalTrials.gov/show/NCT02938988 | Completed | University of Sao Paulo | 2016-10-31 |
| NCT02895802 | Assessing the Feasibility of the Use of Visual Aids in Patient Education in Adults With Down Syndrome (DS) | https://ClinicalTrials.gov/show/NCT02895802 | Completed | Advocate Health Care | 2016-12-31 |
| NCT02882698 | Performance Analysis in Down Syndrome on Mobile Phone | https://ClinicalTrials.gov/show/NCT02882698 | Completed | University of Sao Paulo | 2016-11-30 |
| NCT02759887 | Relationship Between Down Syndrome (DS) and Alzheimer’s Disease (AD) | https://ClinicalTrials.gov/show/NCT02759887 | Completed | St. Joseph’s Hospital and Medical Center, Phoenix | 2018-12-31 |
| NCT02732431 | Obstructive Sleep Apnea and Down Syndrome: Clinical Examination Issue | https://ClinicalTrials.gov/show/NCT02732431 | Completed | Fondation Lenval | 2014-12-31 |
| NCT02719600 | Motor Learning Through Virtual Reality Task in Individuals With Down Syndrome | https://ClinicalTrials.gov/show/NCT02719600 | Completed | University of Sao Paulo | 2016-03-31 |
| NCT02651493 | Digital Dysmorphology Project | https://ClinicalTrials.gov/show/NCT02651493 | Recruiting | Children’s National Research Institute | 2023-12-31 |
| NCT02738450 | Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome | https://ClinicalTrials.gov/show/NCT02738450 | Completed | AC Immune SA | 2020-06-30 |
| NCT02561754 | Weight Management for Adolescents With IDD | https://ClinicalTrials.gov/show/NCT02561754 | Active, not recruiting | University of Kansas Medical Center | 2020-05-12 |
| NCT02521493 | Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome | https://ClinicalTrials.gov/show/NCT02521493 | Recruiting | Children’s Oncology Group | 2023-03-31 |
| NCT02481765 | Feasibility and Dose Tolerability of HD-tDCS in Healthy Adults and Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT02481765 | Completed | University of Wisconsin, Madison | 2016-05-20 |
| NCT01684670 | Intensive Dysarthria Sessions in Adults and Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT01684670 | Completed | Duke University | 2016-05-31 |
| NCT02432716 | Investigation of the Safety of Intranasal Glulisine in Down Syndrome | https://ClinicalTrials.gov/show/NCT02432716 | Completed | HealthPartners Institute | 2018-10-18 |
| NCT02424474 | T21,18 and 13 Screening by Cell Free Fetal DNA in Low Risk Patients | https://ClinicalTrials.gov/show/NCT02424474 | Completed | Assistance Publique - Hôpitaux de Paris | 2016-09-30 |
| NCT02421276 | Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome | https://ClinicalTrials.gov/show/NCT02421276 | Recruiting | University of Colorado, Denver | 2020-01-31 |
| NCT02380638 | Effects of Whole-body Vibration Training on Body Composition in Adolescents With and Without Down Syndrome | https://ClinicalTrials.gov/show/NCT02380638 | Completed | Universidad de Zaragoza | 2012-06-30 |
| NCT02344108 | A Pilot Study to Evaluate the Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Obstructive Sleep Apnea | https://ClinicalTrials.gov/show/NCT02344108 | Active, not recruiting | Massachusetts Eye and Ear Infirmary | 2021-08-31 |
| NCT02304302 | Down Syndrome Memantine Follow-up Study | https://ClinicalTrials.gov/show/NCT02304302 | Active, not recruiting | University Hospitals Cleveland Medical Center | 2020-11-30 |
| NCT02241356 | The Effect of Bifocals in Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT02241356 | Completed | Radboud University | 2017-06-30 |
| NCT02158390 | Phenotypic Specific Communication Intervention for Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT02158390 | Completed | Vanderbilt University | 2017-08-30 |
| NCT01313325 | Hippotherapy to Improve the Balance of Children With Movement Disorders | https://ClinicalTrials.gov/show/NCT01313325 | Completed | Central Michigan University | 2007-12-31 |
| NCT02046889 | A Bicycle Training Intervention | https://ClinicalTrials.gov/show/NCT02046889 | Completed | University of Michigan | 2012-08-31 |
| NCT01925742 | Study of the Efficacy of New Non-invasive Prenatal Tests for Screening for Fetal Trisomies Using Maternal Blood | https://ClinicalTrials.gov/show/NCT01925742 | Completed | CHU de Quebec-Universite Laval | 2017-06-30 |
| NCT01889550 | Use of eHealth in Communication With Patients About Prenatal Diagnosis | https://ClinicalTrials.gov/show/NCT01889550 | Completed | Odense University Hospital | 2014-08-31 |
| NCT01832753 | Treatment Trial of Subclinical Hypothyroidism in Down Syndrome | https://ClinicalTrials.gov/show/NCT01832753 | Completed | Children’s Hospital of Philadelphia | 2017-10-18 |
| NCT01808508 | Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT01808508 | Completed | Children’s Hospital of Philadelphia | 2014-03-31 |
| NCT01794013 | DIR/ Floortimeâ„¢ Parent Training Intervention for the Children With Developmental Disabilities | https://ClinicalTrials.gov/show/NCT01794013 | Completed | Mahidol University | 2016-12-31 |
| NCT01791725 | A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia | https://ClinicalTrials.gov/show/NCT01791725 | Completed | OPKO Health, Inc. | 2014-06-30 |
| NCT01778946 | Nicotine Treatment of Cognitive Decline in Down Syndrome | https://ClinicalTrials.gov/show/NCT01778946 | Recruiting | Vanderbilt University Medical Center | 2020-12-31 |
| NCT01758718 | Eyelash Line Resection for Entropion Associated With Down’s Syndrome | https://ClinicalTrials.gov/show/NCT01758718 | Completed | Kyorin University | 2012-03-31 |
| NCT01699711 | Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool | https://ClinicalTrials.gov/show/NCT01699711 | Completed | Parc de Salut Mar | 2014-06-30 |
| NCT01667367 | A Molecular and Functional Brain Imaging Study in Individuals With Down Syndrome and Healthy Controls Following Single Dose RG1662 | https://ClinicalTrials.gov/show/NCT01667367 | Completed | Hoffmann-La Roche | 2013-10-31 |
| NCT02024789 | A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) | https://ClinicalTrials.gov/show/NCT02024789 | Completed | Hoffmann-La Roche | 2016-05-04 |
| NCT01598350 | Gait in Children With Down Syndrome While Wearing Orthoses | https://ClinicalTrials.gov/show/NCT01598350 | Completed | University of Puget Sound | 2011-06-30 |
| NCT01594346 | Multicenter Vitamin E Trial in Aging Persons With Down Syndrome | https://ClinicalTrials.gov/show/NCT01594346 | Completed | New York State Institute for Basic Research | 2010-04-30 |
| NCT01576705 | Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children | https://ClinicalTrials.gov/show/NCT01576705 | Completed | Institut Jerome Lejeune | 2017-12-14 |
| NCT01436955 | A Study of RG1662 in Individuals With Down Syndrome | https://ClinicalTrials.gov/show/NCT01436955 | Completed | Hoffmann-La Roche | 2013-09-30 |
| NCT01394796 | Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. | https://ClinicalTrials.gov/show/NCT01394796 | Completed | Parc de Salut Mar | 2011-02-28 |
| NCT01379443 | Rehabilitation of Children With Multiple Disabilities | https://ClinicalTrials.gov/show/NCT01379443 | Completed | Children’s Treatment Network | 2009-12-31 |
| NCT04390321 | Application of LLM Care and Related Affective Computing Systems on Persons With Special Needs | https://ClinicalTrials.gov/show/NCT04390321 | Active, not recruiting | Aristotle University Of Thessaloniki | 2022-01-01 |
| NCT04293120 | Training Balance Among People With Neurodevelopmental Disabilities | https://ClinicalTrials.gov/show/NCT04293120 | Recruiting | University of Hartford | 2023-05-31 |
| NCT04227197 | Down Syndrome Clinic to You | https://ClinicalTrials.gov/show/NCT04227197 | Completed | Massachusetts General Hospital | 2019-05-15 |
| NCT04156607 | The Effects of Kinesiotaping on Balance in Children With Down Syndrome. | https://ClinicalTrials.gov/show/NCT04156607 | Completed | Gazi University | 2018-05-15 |
| NCT04048759 | The Promotion of Physical Activity for the Prevention of Alzheimer’s Disease in Adults With Down Syndrome | https://ClinicalTrials.gov/show/NCT04048759 | Recruiting | University of Kansas Medical Center | 2024-01-01 |
| NCT04020302 | Self-Monitoring Shopping Intervention | https://ClinicalTrials.gov/show/NCT04020302 | Completed | Columbia University | 2019-12-15 |
| NCT03935620 | Delivering Early Intervention to Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT03935620 | Recruiting | Oregon Health and Science University | 2020-03-01 |
| NCT03903666 | Anomalies of Nocturnal Gaz Exchanges in Patients With Down Syndrome | https://ClinicalTrials.gov/show/NCT03903666 | Recruiting | Institut Jerome Lejeune | 2020-06-30 |
| NCT03901261 | Cohort Study of Adult Patients With Down Syndrome at Risk of Developing Alzheimer’s Disease (TriAL21) | https://ClinicalTrials.gov/show/NCT03901261 | Recruiting | Institut Jerome Lejeune | 2023-03-31 |
| NCT03771469 | Validation of Sleep Questionnaires in the Down Syndrome Population | https://ClinicalTrials.gov/show/NCT03771469 | Recruiting | Oregon Health and Science University | 2020-09-30 |
| NCT03764761 | Storybook Reading in Individuals With Down Syndrome | https://ClinicalTrials.gov/show/NCT03764761 | Recruiting | Penn State University | 2020-11-30 |
| NCT03687619 | Cognitive Orientation to Daily Occupational Performance and Conductive Education Approaches on Down Syndrome | https://ClinicalTrials.gov/show/NCT03687619 | Active, not recruiting | Eastern Mediterranean University | 2019-12-22 |
| NCT03684512 | Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities | https://ClinicalTrials.gov/show/NCT03684512 | Recruiting | University of Kansas | 2022-07-24 |
| NCT03677245 | Balance Bike Training in Down Syndrome | https://ClinicalTrials.gov/show/NCT03677245 | Completed | University of Mississippi Medical Center | 2019-06-01 |
| NCT03653143 | JASPER Intervention in Down Syndrome | https://ClinicalTrials.gov/show/NCT03653143 | Recruiting | Boston Children’s Hospital | 2019-12-01 |
| NCT03624556 | Pediatric Exploratory Research Study of EGCG Use and Safety (PERSEUS) | https://ClinicalTrials.gov/show/NCT03624556 | Active, not recruiting | Parc de Salut Mar | 2020-03-29 |
| NCT03551418 | Learning by Repetitive Viewing of Peer Modeling Patient Education Videos by Adults With Down Syndrome | https://ClinicalTrials.gov/show/NCT03551418 | Recruiting | Advocate Health Care | 2020-06-09 |
| NCT03544840 | Investigating Trunk Control in Young Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT03544840 | Completed | Texas Woman’s University | 2019-01-31 |
| NCT03538925 | Building Sentences With Preschoolers Who Use AAC | https://ClinicalTrials.gov/show/NCT03538925 | Recruiting | University of Central Florida | 2023-06-30 |
| NCT03522337 | Oral Health Promotion Among Preschool Children With Special Needs | https://ClinicalTrials.gov/show/NCT03522337 | Completed | The University of Hong Kong | 2018-09-28 |
| NCT03441685 | Strategies for Teaching Verbs | https://ClinicalTrials.gov/show/NCT03441685 | Recruiting | Vanderbilt University Medical Center | 2020-12-16 |
| NCT01190930 | Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma | https://ClinicalTrials.gov/show/NCT01190930 | Active, not recruiting | Children’s Oncology Group | 2019-03-31 |
| NCT01176019 | An Interactive Informed Consent and Education Program for Pregnant Women | https://ClinicalTrials.gov/show/NCT01176019 | Completed | Northwestern University | 2011-03-31 |
| NCT01148121 | Assessment of Bone Density and Bone Turnover Markers in Patients With Down Syndrome and Comparison to the Ts65Dn Model | https://ClinicalTrials.gov/show/NCT01148121 | Completed | University of Arkansas | 2015-08-31 |
| NCT01112683 | Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome | https://ClinicalTrials.gov/show/NCT01112683 | Completed | University of Colorado, Denver | 2011-07-31 |
| NCT00928304 | Phase II Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid. | https://ClinicalTrials.gov/show/NCT00928304 | Completed | Life Molecular Imaging SA | 2011-01-31 |
| NCT00891917 | Liq-NOL Efficacy in Pediatric Patients With Down Syndrome | https://ClinicalTrials.gov/show/NCT00891917 | Completed | Children’s Hospital Medical Center, Cincinnati | 2012-11-30 |
| NCT00825175 | Treadmill Training and Orthotic Use in Infants With Down Syndrome | https://ClinicalTrials.gov/show/NCT00825175 | Completed | University of Michigan | 2008-06-30 |
| NCT04293380 | The Role of Amniotic Fluid Biochemical Markers for Down Syndrome Diagnosis | https://ClinicalTrials.gov/show/NCT04293380 | Recruiting | Karadeniz Technical University | 2020-06-01 |
| NCT01084135 | Rivastigmine Study in Adolescents With Down Syndrome | https://ClinicalTrials.gov/show/NCT01084135 | Completed | Duke University | 2014-02-28 |
| NCT04124471 | Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 1) | https://ClinicalTrials.gov/show/NCT04124471 | Recruiting | Children’s Hospital of Philadelphia | 2022-10-31 |
| NCT03783338 | Interaction Effects of Vitamin D Supplementation and Aerobic Exercises on Balance and Physical Performance in Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT03783338 | Completed | Cairo University | 2019-03-02 |
| NCT03286634 | ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016 | https://ClinicalTrials.gov/show/NCT03286634 | Recruiting | National Hospital Organization Nagoya Medical Center | 2028-03-31 |
| NCT02094053 | A Double-blind, Placebo-controlled Comparative Study and Open-label Extension Study to Confirm the Efficacy and Safety of E2020 in Subjects With Down Syndrome Having Regression Symptoms and Disabled Activities of Daily Living. | https://ClinicalTrials.gov/show/NCT02094053 | Completed | Eisai Inc. | 2016-09-16 |
| NCT01256112 | Parent Supported Weight Reduction in Down Syndrome | https://ClinicalTrials.gov/show/NCT01256112 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 2010-03-31 |
| NCT00748007 | Efficacy of Rivastigmine in Patients With Down Syndrome | https://ClinicalTrials.gov/show/NCT00748007 | Completed | National Taiwan University Hospital | 2009-12-31 |
| NCT00689988 | Augmentative and Alternative Communication (AAC) and Lexical Gain in Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT00689988 | Completed | University of Sao Paulo | 2007-10-31 |
| NCT00570128 | Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In Treating Cognitive Dysfunction Exhibited By Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT00570128 | Completed | Eisai Inc. | 2008-09-30 |
| NCT00394290 | Down Syndrome and Continuous Positive Pressure Therapy | https://ClinicalTrials.gov/show/NCT00394290 | Completed | Institut Jerome Lejeune | 2012-10-31 |
| NCT00378456 | Vitamins and Minerals for Children With Downs Syndrome | https://ClinicalTrials.gov/show/NCT00378456 | Completed | Institute of Child Health | NA |
| NCT00294593 | Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT00294593 | Completed | Institut Jerome Lejeune | NA |
| NCT00003593 | Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome | https://ClinicalTrials.gov/show/NCT00003593 | Completed | Children’s Oncology Group | 2007-03-31 |
#If less then 500 studies
| nct_id | brief_title | link | overall_status | source | primary_completion_date |
|---|---|---|---|---|---|
| NCT04278404 | Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) | https://ClinicalTrials.gov/show/NCT04278404 | Recruiting | Duke University | 2024-04-24 |
| NCT03375359 | First Trimester Screening for Trisomy 21, 18, 13 and 22q11.2 Deletion Syndrome | https://ClinicalTrials.gov/show/NCT03375359 | Recruiting | University Hospital Tuebingen | 2020-12-31 |
| NCT03087357 | VAlidation of a Lower Cost aneUploidy scrEen | https://ClinicalTrials.gov/show/NCT03087357 | Active, not recruiting | Women and Infants Hospital of Rhode Island | 2020-06-01 |
| NCT02864108 | The Crnic Institute Human Trisome Project Biobank | https://ClinicalTrials.gov/show/NCT02864108 | Recruiting | University of Colorado, Denver | 2036-07-31 |
| NCT02859389 | Neurocognitive and Psychosocial Outcomes in Survivors of Childhood Leukemia With Down Syndrome | https://ClinicalTrials.gov/show/NCT02859389 | Completed | St. Jude Children’s Research Hospital | 2019-01-31 |
| NCT02787486 | Expanded Noninvasive Genomic Medical Assessment: The Enigma Study | https://ClinicalTrials.gov/show/NCT02787486 | Completed | Progenity, Inc. | 2018-09-30 |
| NCT02639312 | Natural History of Craniofacial Anomalies and Developmental Growth Variants | https://ClinicalTrials.gov/show/NCT02639312 | Recruiting | National Institutes of Health Clinical Center (CC) | 2036-04-18 |
| NCT02451657 | Non-drug Study to Evaluate the Suitability of Neurocognitive Tests and Functioning Scales for the Measurement of Cognitive and Functioning Changes in Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT02451657 | Completed | Hoffmann-La Roche | 2016-06-30 |
| NCT02443597 | Can Increased Body Mass Index Prevent Adequate Ultrasound Examination for Trisomy 21 Risk Assessment? | https://ClinicalTrials.gov/show/NCT02443597 | Completed | Benha University | 2015-12-31 |
| NCT02431117 | Non-drug Study to Assess the Suitability of Assessment Scales in Japanese Individuals With Down Syndrome Aged 6-30 | https://ClinicalTrials.gov/show/NCT02431117 | Completed | Chugai Pharmaceutical | 2016-07-31 |
| NCT02430584 | Whole Blood Specimen Collection From Pregnant Subjects | https://ClinicalTrials.gov/show/NCT02430584 | Active, not recruiting | Progenity, Inc. | 2020-03-31 |
| NCT02317965 | Non-Invasive Screening for Fetal Aneuploidy | https://ClinicalTrials.gov/show/NCT02317965 | Active, not recruiting | Progenity, Inc. | 2018-11-30 |
| NCT02288702 | Comparison of Bispectral Index Values in Patients With and Without Down’s Syndrome | https://ClinicalTrials.gov/show/NCT02288702 | Recruiting | Milton S. Hershey Medical Center | 2021-02-28 |
| NCT02278874 | High Risk Multiple Gestation Study | https://ClinicalTrials.gov/show/NCT02278874 | Completed | Natera, Inc. | 2018-12-01 |
| NCT02278536 | Multiple Gestation Study | https://ClinicalTrials.gov/show/NCT02278536 | Completed | Natera, Inc. | 2019-03-31 |
| NCT02201862 | Non-Invasive Chromosomal Evaluation of Trisomy Study | https://ClinicalTrials.gov/show/NCT02201862 | Completed | Roche Sequencing Solutions | 2019-08-01 |
| NCT02141971 | Down Syndrome Biomarker Initiative (DSBI) | https://ClinicalTrials.gov/show/NCT02141971 | Completed | University of California, San Diego | 2017-04-15 |
| NCT02109770 | Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA | https://ClinicalTrials.gov/show/NCT02109770 | Completed | Natera, Inc. | 2019-06-30 |
| NCT01303133 | Natural History of Amyloid Deposition in Adults With Down Syndrome | https://ClinicalTrials.gov/show/NCT01303133 | Completed | University of Pittsburgh | 2018-03-31 |
| NCT01966991 | Prenatal Screening for Down Syndrome With DNAFirst | https://ClinicalTrials.gov/show/NCT01966991 | Completed | Women and Infants Hospital of Rhode Island | 2015-07-31 |
| NCT01950624 | DS-Connect {TM}: The Down Syndrome Registry | https://ClinicalTrials.gov/show/NCT01950624 | Recruiting | National Institutes of Health Clinical Center (CC) | 2024-05-26 |
| NCT01931644 | At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions | https://ClinicalTrials.gov/show/NCT01931644 | Recruiting | Sanguine Biosciences | 2025-08-31 |
| NCT01920633 | A Screening Protocol to Assess Adults and Adolescents With Down Syndrome for Eligibility For Upcoming Study of RG1662 (Study BP27832) | https://ClinicalTrials.gov/show/NCT01920633 | Completed | Hoffmann-La Roche | 2015-01-31 |
| NCT01902407 | Computer Models of Airways in Children and Young Adults With Sleep Apnea and Down Syndrome | https://ClinicalTrials.gov/show/NCT01902407 | Enrolling by invitation | Children’s Hospital Medical Center, Cincinnati | 2027-12-31 |
| NCT01852708 | Development of Non-invasive Prenatal Screening Test for Microdeletions Based on Fetal DNA Isolated From Maternal Blood | https://ClinicalTrials.gov/show/NCT01852708 | Recruiting | Natera, Inc. | 2020-11-30 |
| NCT01821300 | Down Syndrome Metabolic Health Study | https://ClinicalTrials.gov/show/NCT01821300 | Completed | Children’s Hospital of Philadelphia | 2017-08-25 |
| NCT01663675 | Trisomy 21 in Adulthood | https://ClinicalTrials.gov/show/NCT01663675 | Recruiting | University Hospital, Strasbourg, France | 2019-10-31 |
| NCT01663350 | Comparison of Aneuploidy Risk Evaluations | https://ClinicalTrials.gov/show/NCT01663350 | Completed | Verinata Health, Inc. | 2013-07-31 |
| NCT01597063 | Clinical Evaluation of the SEQureDx Trisomy Test in Low Risk Pregnancies | https://ClinicalTrials.gov/show/NCT01597063 | Completed | Sequenom, Inc. | 2014-02-28 |
| NCT01580384 | A Non-Drug Study of The Suitability of Neurocognitive Tests And Functioning Scales For The Measurement of Cognitive And Functioning Changes in Individuals With Down Syndrome | https://ClinicalTrials.gov/show/NCT01580384 | Completed | Hoffmann-La Roche | 2014-01-31 |
| NCT01555346 | Clinical Evaluation of the SEQureDx T21 Test In High Risk Pregnancies | https://ClinicalTrials.gov/show/NCT01555346 | Completed | Sequenom, Inc. | 2014-10-31 |
| NCT01545674 | Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial | https://ClinicalTrials.gov/show/NCT01545674 | Active, not recruiting | Natera, Inc. | 2014-04-30 |
| NCT01511575 | Studying Biomarker Expression in Samples From Patients With Down Syndrome and Acute Myeloid Leukemia or Other Transient Myeloproliferative Disorder | https://ClinicalTrials.gov/show/NCT01511575 | Completed | Children’s Oncology Group | 2016-05-31 |
| NCT01511458 | Non-invasive Chromosomal Examination of Trisomy Study | https://ClinicalTrials.gov/show/NCT01511458 | Completed | Roche Sequencing Solutions | 2013-11-30 |
| NCT01507441 | Studying DNA in Samples From Younger Patients With Down Syndrome and Acute Myeloid Leukemia Treated on COG-AAML0431 Clinical Trial | https://ClinicalTrials.gov/show/NCT01507441 | Completed | Children’s Oncology Group | 2016-05-31 |
| NCT01429389 | Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy | https://ClinicalTrials.gov/show/NCT01429389 | Recruiting | Sequenom, Inc. | 2022-12-31 |
| NCT01390558 | Gait Parameters of Persons With Down Syndrome With and Without Orthotics Using GaitRite | https://ClinicalTrials.gov/show/NCT01390558 | Completed | Oregon Health and Science University | 2018-08-27 |
| NCT04241042 | Clinical Validation of the Bordeaux Maze Test | https://ClinicalTrials.gov/show/NCT04241042 | Recruiting | Parc de Salut Mar | 2020-04-30 |
| NCT04208685 | Evaluating Cognitive Outcomes in Down Syndrome | https://ClinicalTrials.gov/show/NCT04208685 | Recruiting | Children’s Hospital Medical Center, Cincinnati | 2023-06-30 |
| NCT04149197 | Down Syndrome Clinical Trials - Study of Alzheimer’s Disease in Down Syndrome | https://ClinicalTrials.gov/show/NCT04149197 | Recruiting | LuMind IDSC Foundation | 2022-03-30 |
| NCT04035967 | Investigation of Parents’ Anxiety Level and Health Related Quality of Life in Different Types of Physical Disabilities | https://ClinicalTrials.gov/show/NCT04035967 | Completed | Sanko University | 2019-05-01 |
| NCT03942341 | Sleep in Adults With Down Syndrome and Alzheimer’s Disease | https://ClinicalTrials.gov/show/NCT03942341 | Recruiting | Fundació Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau | 2020-03-31 |
| NCT03922165 | Healthy Sleep for Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT03922165 | Recruiting | Brigham and Women’s Hospital | 2020-07-01 |
| NCT02941887 | Global Behavior and Periodontal Disease in Down’s Syndrome Patients | https://ClinicalTrials.gov/show/NCT02941887 | Completed | University of Sao Paulo | 2016-10-31 |
| NCT03635359 | Automated Screen for Fetal Aneuploidy | https://ClinicalTrials.gov/show/NCT03635359 | Enrolling by invitation | BioCeryx | 2019-03-31 |
| NCT03629795 | Serum Sample Collection to Determine Analytical Performance Characteristics of the ADVIA Centaur PAPPA and BhCG Assays | https://ClinicalTrials.gov/show/NCT03629795 | Completed | Axis Shield Diagnostics Ltd | 2018-01-24 |
| NCT03602378 | QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease | https://ClinicalTrials.gov/show/NCT03602378 | Enrolling by invitation | University of Split, School of Medicine | 2021-04-02 |
| NCT03559374 | Study of Vanadis® NIPT for Non-invasive Prenatal Screening of Trisomies (T21, T18 and T13) | https://ClinicalTrials.gov/show/NCT03559374 | Enrolling by invitation | PerkinElmer, Wallac Oy | 2020-04-30 |
| NCT03553706 | Indicators of Growth, Nutritional Status and Comorbide Disorders of Newborns With Down Syndrome | https://ClinicalTrials.gov/show/NCT03553706 | Completed | University Hospital of Split | 2018-05-30 |
| NCT03445962 | 19/5000 (SYNAPSOT21) Predictive Factors of Sleep Apnea Syndrome in Down Syndrome | https://ClinicalTrials.gov/show/NCT03445962 | Active, not recruiting | University Hospital, Grenoble | 2019-12-31 |
| NCT01118507 | Trisomy of Chromosome 21 Diagnosis by High Output Sequencing | https://ClinicalTrials.gov/show/NCT01118507 | Completed | Assistance Publique - Hôpitaux de Paris | 2013-09-30 |
| NCT01052688 | Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies | https://ClinicalTrials.gov/show/NCT01052688 | Recruiting | Sequenom, Inc. | 2021-06-30 |
| NCT01041469 | Pilot Study of Auto-immune Abnormalities Associated With Down Syndrome | https://ClinicalTrials.gov/show/NCT01041469 | Completed | Institut Jerome Lejeune | NA |
| NCT01034280 | Correlations Phenotype / Genotype in Down Syndrome | https://ClinicalTrials.gov/show/NCT01034280 | Completed | Institut Jerome Lejeune | NA |
| NCT00971334 | Noninvasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker | https://ClinicalTrials.gov/show/NCT00971334 | Completed | Sequenom, Inc. | 2011-09-30 |
| NCT00959283 | Study of Blood Samples From Newborns With Down Syndrome | https://ClinicalTrials.gov/show/NCT00959283 | Active, not recruiting | Children’s Oncology Group | 2011-12-30 |
| NCT00951730 | Evaluation of a Simplified Method for Diagnosis of Sleep Apnea in Children and Adults With Down Syndrome | https://ClinicalTrials.gov/show/NCT00951730 | Completed | Centre Hospitalier Universitaire de Saint Etienne | 2015-02-28 |
| NCT00879515 | Examining Social, Emotional, and Cognitive Functioning in People With Fragile X and Down Syndromes | https://ClinicalTrials.gov/show/NCT00879515 | Completed | University of California, Davis | 2010-09-30 |
| NCT00877292 | A New Prenatal Blood Test for Down Syndrome | https://ClinicalTrials.gov/show/NCT00877292 | Completed | Women and Infants Hospital of Rhode Island | 2011-01-31 |
| NCT00864461 | Frequency of Metabolic Syndrome in Down Syndrome Patients | https://ClinicalTrials.gov/show/NCT00864461 | Completed | Universidad de Guanajuato | 2009-12-21 |
| NCT00847990 | Non-Invasive Screening for Fetal Aneuploidy | https://ClinicalTrials.gov/show/NCT00847990 | Completed | Sequenom, Inc. | 2011-04-30 |
| NCT00844259 | Functional Communicative Profile of Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT00844259 | Completed | University of Sao Paulo | 2007-10-31 |
| NCT01256606 | Prenatal Test for Fetal Aneuploidy Detection | https://ClinicalTrials.gov/show/NCT01256606 | Completed | Roche Sequencing Solutions | 2011-11-30 |
| NCT00770458 | Non-Invasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker | https://ClinicalTrials.gov/show/NCT00770458 | Completed | Sequenom, Inc. | 2009-10-31 |
| NCT00668980 | Symbolic Representation in Young Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT00668980 | Completed | University of Sao Paulo | 2009-04-30 |
| NCT00643552 | Muscle Strength, Physical Work Capacity and Functional Performance in Individuals With Down Syndrome | https://ClinicalTrials.gov/show/NCT00643552 | Completed | State University of New York - Upstate Medical University | NA |
| NCT00478296 | Pulmonary Hypertension in Trisomy 21 Patients | https://ClinicalTrials.gov/show/NCT00478296 | Completed | Children’s Healthcare of Atlanta | 2007-02-28 |
| NCT00287417 | Early Ultrasound and Maternal Biochemical Markers to Evaluate the Risk of Down Syndrome During the First Trimester | https://ClinicalTrials.gov/show/NCT00287417 | Completed | University Hospital, Strasbourg, France | NA |
| NCT00695695 | The Experience of Caregivers of Children With Down Syndrome | https://ClinicalTrials.gov/show/NCT00695695 | Completed | National Institutes of Health Clinical Center (CC) | NA |
| NCT00005190 | Reproduction and Survival After Cardiac Defect Repair | https://ClinicalTrials.gov/show/NCT00005190 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | NA |
#If less then 500 registries
| nct_id | brief_title | link | overall_status | source | primary_completion_date |
|---|---|---|---|---|---|
| NCT02612376 | Rocky Mountain Alzheimer’s Disease Center Longitudinal Biomarker and Clinical Phenotyping Study | https://ClinicalTrials.gov/show/NCT02612376 | Recruiting | University of Colorado, Denver | 2030-12-31 |
| NCT02381457 | SNP-based Microdeletion and Aneuploidy RegisTry (SMART) | https://ClinicalTrials.gov/show/NCT02381457 | Active, not recruiting | Natera, Inc. | 2020-04-30 |