Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 166
interventional 94
Observational 70
Registry 2

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Behavioral 21
Other 18
Drug 12
Device 11
Drug|placebo 10
Procedure 5
Diagnostic Test 3
Dietary Supplement|placebo 2
Drug|Other 2
Behavioral|Device 1
Behavioral|Dietary Supplement|Other 1
Biological|Device 1
Biological|Drug 1
Biological|placebo 1
Combination Product 1
Device|Drug|Procedure 1
Device|placebo 1
Dietary Supplement 1
Other|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 47
France 8
Spain 5
NA 4
Brazil 3
United Kingdom 3
Canada 2
Greece 2
Japan 2
Turkey 2
Belgium 1
Canada|United States|Australia|Netherlands|New Zealand|Puerto Rico|Switzerland 1
China 1
Cyprus 1
Denmark 1
Egypt 1
Hong Kong|Japan|Malaysia|Singapore|Taiwan 1
Netherlands 1
Taiwan 1
Thailand 1
United States|Argentina|Canada|France|Italy|Mexico|New Zealand|Singapore|Spain|United Kingdom 1
United States|Australia|Canada|Ireland|New Zealand|Puerto Rico|Switzerland 1
United States|Australia|Canada|New Zealand|Puerto Rico 1
United States|Australia|Canada|New Zealand|Puerto Rico|Saudi Arabia 1
United States|Brazil 1
United States|United Kingdom 1

Sites per Study

Site_count Study_Count
1 71
2 8
3 3
4 1
5 1
6 1
9 2
10 1
31 1
37 1
185 1
211 1
237 1
244 1

Phase

Phase Study_Count
N/A 66
Phase 2 12
Phase 1 6
Phase 3 6
Phase 1/Phase 2 2
Phase 2/Phase 3 1
Phase 4 1

Number of Arms

Number_of_Arms Count_of_Studies
1 27
2 45
3 10
4 5
6 1
7 1
8 1
NA 4

Enrollment Metrics by Phase

Measure N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 5.0000 12.0000 15.00 23.00000 120 175.000 42
1st Qu. 17.0000 13.7500 21.75 34.75000 120 254.500 42
Median 40.0000 25.5000 28.50 73.50000 120 302.500 42
Mean 167.4615 111.8333 28.50 88.16667 120 2850.667 42
3rd Qu. 80.0000 121.2500 35.25 127.50000 120 5127.250 42
Max. 3819.0000 445.0000 42.00 200.00000 120 9350.000 42

Trial Group Type

group_type Group_Count
Experimental 97
Active Comparator 33
Other 23
Placebo Comparator 21
No Intervention 13
NA 4
Sham Comparator 1

Intervention Model

intervention_model Study_Count
Parallel Assignment 52
Single Group Assignment 31
Crossover Assignment 10
Sequential Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 57
Health Services Research 7
Diagnostic 6
Prevention 5
Supportive Care 5
Screening 4
Other 3
NA 3
Basic Science 2
Device Feasibility 2

Observational Studies

Studies by Country

Country Study_Count
United States 30
France 7
NA 4
Brazil 3
United States|Canada 3
Croatia 2
Spain 2
Australia|Belgium|Canada|Portugal|Spain|United Kingdom 1
France|United States|Spain 1
Germany 1
Italy 1
Japan 1
Mexico 1
Saudi Arabia 1
Turkey 1
United Kingdom 1
United States|Argentina|Australia|Canada|Czech Republic|Hungary|Ireland|Israel|Italy|Spain 1
United States|Argentina|Canada|France|Italy|Spain|United Kingdom 1
United States|Argentina|Canada|Mexico|New Zealand|Singapore|Spain 1
United States|Australia|Canada|Puerto Rico 1
United States|Belgium|Canada|Italy|Netherlands|Sweden 1
United States|Canada|Ireland|Italy|Korea, Republic of|Spain 1
United States|Canada|Italy 1
United States|France 1
United States|India|Malaysia 1
United States|Spain|Taiwan 1

Sites per Study

Site_count Study_Count
1 32
2 7
3 3
4 1
6 3
7 3
8 2
9 1
10 3
12 2
14 1
16 1
22 1
25 1
26 1
27 2
29 2
35 2
36 1
189 1

Enrollment Metrics

Measure Observational
Min 1.000
1st Qu 73.000
Median 260.000
Mean 3267.536
3rd Qu 2000.000
Max 100000.000

Observation Model

observational_model Study_Count
Cohort 31
Case-Only 11
Case-Control 10
Case Control 6
NA 5
Family-Based 3
Other 3
Case-Crossover 1

Time Perspective

time_perspective Study_Count
Prospective 46
Cross-Sectional 18
Retrospective 5
NA 1

Registries

Studies by Country

Country Study_Count
United States 1
United States|Australia|Ireland|Spain|Sweden|United Kingdom 1

Sites per Study

Site_count Study_Count
1 1
21 1

Enrollment Metrics

Measure Registries
Min 800
1st Qu 5840
Median 10880
Mean 10880
3rd Qu 15920
Max 20960

Registry Model

observational_model Study_Count
Case-Control 1
Cohort 1

Time Perspective

time_perspective Study_Count
Prospective 2

Follow-up

target_duration Study_Count
2 Years 1
25 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03914625 A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia https://ClinicalTrials.gov/show/NCT03914625 Recruiting National Cancer Institute (NCI) 2027-06-30
NCT03367793 Spectacles for Patients With Down Syndrome https://ClinicalTrials.gov/show/NCT03367793 Completed University of Houston 2019-06-10
NCT03267602 Role of Sleep Apnea in the Neuropsychological Function in Down Syndrome People https://ClinicalTrials.gov/show/NCT03267602 Completed National Taiwan University Hospital 2016-12-31
NCT03210675 Early Detection and Treatment of Respiratory Sleep Disorders in Children With Down Syndrome https://ClinicalTrials.gov/show/NCT03210675 Active, not recruiting Institut Jerome Lejeune 2022-12-31
NCT03206957 Correlation Between Optic Nerve Vessel Anomalies, Serum Angiogenic Factors and Renal Anomalies in Down Syndrome Children https://ClinicalTrials.gov/show/NCT03206957 Recruiting Queen Fabiola Children’s University Hospital 2019-06-01
NCT03200041 Clinical Evaluation of the IONA Test for Non-invasive Pre Natal Screening in Twin Pregnancies https://ClinicalTrials.gov/show/NCT03200041 Completed Premaitha Health 2019-12-31
NCT03192540 The Impact of an 8-week Supported Exercise Program on Fitness and Symptoms in Adolescents With Down Syndrome https://ClinicalTrials.gov/show/NCT03192540 Active, not recruiting Boston Children’s Hospital 2019-01-12
NCT03135236 Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome https://ClinicalTrials.gov/show/NCT03135236 Completed Advocate Health Care 2017-09-30
NCT03126734 Effects of Infant Massage on Acceptance, Commitment and Conscience of Influence of Parents With Down Syndrome Babies https://ClinicalTrials.gov/show/NCT03126734 Completed University of Seville 2017-03-15
NCT03084497 Effects of Infant Massage on Development of Down Syndrome Babies https://ClinicalTrials.gov/show/NCT03084497 Completed University of Seville 2016-09-30
NCT03058640 Effects of Karate in Adolescents With Down Syndrome https://ClinicalTrials.gov/show/NCT03058640 Completed University of Michigan 2019-03-31
NCT02996175 Treatment of Sleep Disturbances in School-age Children With Down Syndrome https://ClinicalTrials.gov/show/NCT02996175 Completed Children’s Hospital Medical Center, Cincinnati 2018-05-31
NCT02971254 The Effects of Inhalational Anaesthetics in Cognitive Functions in Down Syndrome Patients https://ClinicalTrials.gov/show/NCT02971254 Completed Asklepieion Voulas General Hospital 2019-01-06
NCT02938988 Antimicrobial Photodynamic Therapy as an Adjunct Treatment for Periodontal Disease in Down’s Syndrome Patients https://ClinicalTrials.gov/show/NCT02938988 Completed University of Sao Paulo 2016-10-31
NCT02895802 Assessing the Feasibility of the Use of Visual Aids in Patient Education in Adults With Down Syndrome (DS) https://ClinicalTrials.gov/show/NCT02895802 Completed Advocate Health Care 2016-12-31
NCT02882698 Performance Analysis in Down Syndrome on Mobile Phone https://ClinicalTrials.gov/show/NCT02882698 Completed University of Sao Paulo 2016-11-30
NCT02759887 Relationship Between Down Syndrome (DS) and Alzheimer’s Disease (AD) https://ClinicalTrials.gov/show/NCT02759887 Completed St. Joseph’s Hospital and Medical Center, Phoenix 2018-12-31
NCT02732431 Obstructive Sleep Apnea and Down Syndrome: Clinical Examination Issue https://ClinicalTrials.gov/show/NCT02732431 Completed Fondation Lenval 2014-12-31
NCT02719600 Motor Learning Through Virtual Reality Task in Individuals With Down Syndrome https://ClinicalTrials.gov/show/NCT02719600 Completed University of Sao Paulo 2016-03-31
NCT02651493 Digital Dysmorphology Project https://ClinicalTrials.gov/show/NCT02651493 Recruiting Children’s National Research Institute 2023-12-31
NCT02738450 Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome https://ClinicalTrials.gov/show/NCT02738450 Completed AC Immune SA 2020-06-30
NCT02561754 Weight Management for Adolescents With IDD https://ClinicalTrials.gov/show/NCT02561754 Active, not recruiting University of Kansas Medical Center 2020-05-12
NCT02521493 Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome https://ClinicalTrials.gov/show/NCT02521493 Recruiting Children’s Oncology Group 2023-03-31
NCT02481765 Feasibility and Dose Tolerability of HD-tDCS in Healthy Adults and Children With Down Syndrome https://ClinicalTrials.gov/show/NCT02481765 Completed University of Wisconsin, Madison 2016-05-20
NCT01684670 Intensive Dysarthria Sessions in Adults and Children With Down Syndrome https://ClinicalTrials.gov/show/NCT01684670 Completed Duke University 2016-05-31
NCT02432716 Investigation of the Safety of Intranasal Glulisine in Down Syndrome https://ClinicalTrials.gov/show/NCT02432716 Completed HealthPartners Institute 2018-10-18
NCT02424474 T21,18 and 13 Screening by Cell Free Fetal DNA in Low Risk Patients https://ClinicalTrials.gov/show/NCT02424474 Completed Assistance Publique - Hôpitaux de Paris 2016-09-30
NCT02421276 Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome https://ClinicalTrials.gov/show/NCT02421276 Recruiting University of Colorado, Denver 2020-01-31
NCT02380638 Effects of Whole-body Vibration Training on Body Composition in Adolescents With and Without Down Syndrome https://ClinicalTrials.gov/show/NCT02380638 Completed Universidad de Zaragoza 2012-06-30
NCT02344108 A Pilot Study to Evaluate the Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Obstructive Sleep Apnea https://ClinicalTrials.gov/show/NCT02344108 Active, not recruiting Massachusetts Eye and Ear Infirmary 2021-08-31
NCT02304302 Down Syndrome Memantine Follow-up Study https://ClinicalTrials.gov/show/NCT02304302 Active, not recruiting University Hospitals Cleveland Medical Center 2020-11-30
NCT02241356 The Effect of Bifocals in Children With Down Syndrome https://ClinicalTrials.gov/show/NCT02241356 Completed Radboud University 2017-06-30
NCT02158390 Phenotypic Specific Communication Intervention for Children With Down Syndrome https://ClinicalTrials.gov/show/NCT02158390 Completed Vanderbilt University 2017-08-30
NCT01313325 Hippotherapy to Improve the Balance of Children With Movement Disorders https://ClinicalTrials.gov/show/NCT01313325 Completed Central Michigan University 2007-12-31
NCT02046889 A Bicycle Training Intervention https://ClinicalTrials.gov/show/NCT02046889 Completed University of Michigan 2012-08-31
NCT01925742 Study of the Efficacy of New Non-invasive Prenatal Tests for Screening for Fetal Trisomies Using Maternal Blood https://ClinicalTrials.gov/show/NCT01925742 Completed CHU de Quebec-Universite Laval 2017-06-30
NCT01889550 Use of eHealth in Communication With Patients About Prenatal Diagnosis https://ClinicalTrials.gov/show/NCT01889550 Completed Odense University Hospital 2014-08-31
NCT01832753 Treatment Trial of Subclinical Hypothyroidism in Down Syndrome https://ClinicalTrials.gov/show/NCT01832753 Completed Children’s Hospital of Philadelphia 2017-10-18
NCT01808508 Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome https://ClinicalTrials.gov/show/NCT01808508 Completed Children’s Hospital of Philadelphia 2014-03-31
NCT01794013 DIR/ Floortimeâ„¢ Parent Training Intervention for the Children With Developmental Disabilities https://ClinicalTrials.gov/show/NCT01794013 Completed Mahidol University 2016-12-31
NCT01791725 A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia https://ClinicalTrials.gov/show/NCT01791725 Completed OPKO Health, Inc. 2014-06-30
NCT01778946 Nicotine Treatment of Cognitive Decline in Down Syndrome https://ClinicalTrials.gov/show/NCT01778946 Recruiting Vanderbilt University Medical Center 2020-12-31
NCT01758718 Eyelash Line Resection for Entropion Associated With Down’s Syndrome https://ClinicalTrials.gov/show/NCT01758718 Completed Kyorin University 2012-03-31
NCT01699711 Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool https://ClinicalTrials.gov/show/NCT01699711 Completed Parc de Salut Mar 2014-06-30
NCT01667367 A Molecular and Functional Brain Imaging Study in Individuals With Down Syndrome and Healthy Controls Following Single Dose RG1662 https://ClinicalTrials.gov/show/NCT01667367 Completed Hoffmann-La Roche 2013-10-31
NCT02024789 A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) https://ClinicalTrials.gov/show/NCT02024789 Completed Hoffmann-La Roche 2016-05-04
NCT01598350 Gait in Children With Down Syndrome While Wearing Orthoses https://ClinicalTrials.gov/show/NCT01598350 Completed University of Puget Sound 2011-06-30
NCT01594346 Multicenter Vitamin E Trial in Aging Persons With Down Syndrome https://ClinicalTrials.gov/show/NCT01594346 Completed New York State Institute for Basic Research 2010-04-30
NCT01576705 Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children https://ClinicalTrials.gov/show/NCT01576705 Completed Institut Jerome Lejeune 2017-12-14
NCT01436955 A Study of RG1662 in Individuals With Down Syndrome https://ClinicalTrials.gov/show/NCT01436955 Completed Hoffmann-La Roche 2013-09-30
NCT01394796 Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. https://ClinicalTrials.gov/show/NCT01394796 Completed Parc de Salut Mar 2011-02-28
NCT01379443 Rehabilitation of Children With Multiple Disabilities https://ClinicalTrials.gov/show/NCT01379443 Completed Children’s Treatment Network 2009-12-31
NCT04390321 Application of LLM Care and Related Affective Computing Systems on Persons With Special Needs https://ClinicalTrials.gov/show/NCT04390321 Active, not recruiting Aristotle University Of Thessaloniki 2022-01-01
NCT04293120 Training Balance Among People With Neurodevelopmental Disabilities https://ClinicalTrials.gov/show/NCT04293120 Recruiting University of Hartford 2023-05-31
NCT04227197 Down Syndrome Clinic to You https://ClinicalTrials.gov/show/NCT04227197 Completed Massachusetts General Hospital 2019-05-15
NCT04156607 The Effects of Kinesiotaping on Balance in Children With Down Syndrome. https://ClinicalTrials.gov/show/NCT04156607 Completed Gazi University 2018-05-15
NCT04048759 The Promotion of Physical Activity for the Prevention of Alzheimer’s Disease in Adults With Down Syndrome https://ClinicalTrials.gov/show/NCT04048759 Recruiting University of Kansas Medical Center 2024-01-01
NCT04020302 Self-Monitoring Shopping Intervention https://ClinicalTrials.gov/show/NCT04020302 Completed Columbia University 2019-12-15
NCT03935620 Delivering Early Intervention to Children With Down Syndrome https://ClinicalTrials.gov/show/NCT03935620 Recruiting Oregon Health and Science University 2020-03-01
NCT03903666 Anomalies of Nocturnal Gaz Exchanges in Patients With Down Syndrome https://ClinicalTrials.gov/show/NCT03903666 Recruiting Institut Jerome Lejeune 2020-06-30
NCT03901261 Cohort Study of Adult Patients With Down Syndrome at Risk of Developing Alzheimer’s Disease (TriAL21) https://ClinicalTrials.gov/show/NCT03901261 Recruiting Institut Jerome Lejeune 2023-03-31
NCT03771469 Validation of Sleep Questionnaires in the Down Syndrome Population https://ClinicalTrials.gov/show/NCT03771469 Recruiting Oregon Health and Science University 2020-09-30
NCT03764761 Storybook Reading in Individuals With Down Syndrome https://ClinicalTrials.gov/show/NCT03764761 Recruiting Penn State University 2020-11-30
NCT03687619 Cognitive Orientation to Daily Occupational Performance and Conductive Education Approaches on Down Syndrome https://ClinicalTrials.gov/show/NCT03687619 Active, not recruiting Eastern Mediterranean University 2019-12-22
NCT03684512 Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities https://ClinicalTrials.gov/show/NCT03684512 Recruiting University of Kansas 2022-07-24
NCT03677245 Balance Bike Training in Down Syndrome https://ClinicalTrials.gov/show/NCT03677245 Completed University of Mississippi Medical Center 2019-06-01
NCT03653143 JASPER Intervention in Down Syndrome https://ClinicalTrials.gov/show/NCT03653143 Recruiting Boston Children’s Hospital 2019-12-01
NCT03624556 Pediatric Exploratory Research Study of EGCG Use and Safety (PERSEUS) https://ClinicalTrials.gov/show/NCT03624556 Active, not recruiting Parc de Salut Mar 2020-03-29
NCT03551418 Learning by Repetitive Viewing of Peer Modeling Patient Education Videos by Adults With Down Syndrome https://ClinicalTrials.gov/show/NCT03551418 Recruiting Advocate Health Care 2020-06-09
NCT03544840 Investigating Trunk Control in Young Children With Down Syndrome https://ClinicalTrials.gov/show/NCT03544840 Completed Texas Woman’s University 2019-01-31
NCT03538925 Building Sentences With Preschoolers Who Use AAC https://ClinicalTrials.gov/show/NCT03538925 Recruiting University of Central Florida 2023-06-30
NCT03522337 Oral Health Promotion Among Preschool Children With Special Needs https://ClinicalTrials.gov/show/NCT03522337 Completed The University of Hong Kong 2018-09-28
NCT03441685 Strategies for Teaching Verbs https://ClinicalTrials.gov/show/NCT03441685 Recruiting Vanderbilt University Medical Center 2020-12-16
NCT01190930 Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma https://ClinicalTrials.gov/show/NCT01190930 Active, not recruiting Children’s Oncology Group 2019-03-31
NCT01176019 An Interactive Informed Consent and Education Program for Pregnant Women https://ClinicalTrials.gov/show/NCT01176019 Completed Northwestern University 2011-03-31
NCT01148121 Assessment of Bone Density and Bone Turnover Markers in Patients With Down Syndrome and Comparison to the Ts65Dn Model https://ClinicalTrials.gov/show/NCT01148121 Completed University of Arkansas 2015-08-31
NCT01112683 Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome https://ClinicalTrials.gov/show/NCT01112683 Completed University of Colorado, Denver 2011-07-31
NCT00928304 Phase II Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid. https://ClinicalTrials.gov/show/NCT00928304 Completed Life Molecular Imaging SA 2011-01-31
NCT00891917 Liq-NOL Efficacy in Pediatric Patients With Down Syndrome https://ClinicalTrials.gov/show/NCT00891917 Completed Children’s Hospital Medical Center, Cincinnati 2012-11-30
NCT00825175 Treadmill Training and Orthotic Use in Infants With Down Syndrome https://ClinicalTrials.gov/show/NCT00825175 Completed University of Michigan 2008-06-30
NCT04293380 The Role of Amniotic Fluid Biochemical Markers for Down Syndrome Diagnosis https://ClinicalTrials.gov/show/NCT04293380 Recruiting Karadeniz Technical University 2020-06-01
NCT01084135 Rivastigmine Study in Adolescents With Down Syndrome https://ClinicalTrials.gov/show/NCT01084135 Completed Duke University 2014-02-28
NCT04124471 Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 1) https://ClinicalTrials.gov/show/NCT04124471 Recruiting Children’s Hospital of Philadelphia 2022-10-31
NCT03783338 Interaction Effects of Vitamin D Supplementation and Aerobic Exercises on Balance and Physical Performance in Children With Down Syndrome https://ClinicalTrials.gov/show/NCT03783338 Completed Cairo University 2019-03-02
NCT03286634 ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016 https://ClinicalTrials.gov/show/NCT03286634 Recruiting National Hospital Organization Nagoya Medical Center 2028-03-31
NCT02094053 A Double-blind, Placebo-controlled Comparative Study and Open-label Extension Study to Confirm the Efficacy and Safety of E2020 in Subjects With Down Syndrome Having Regression Symptoms and Disabled Activities of Daily Living. https://ClinicalTrials.gov/show/NCT02094053 Completed Eisai Inc. 2016-09-16
NCT01256112 Parent Supported Weight Reduction in Down Syndrome https://ClinicalTrials.gov/show/NCT01256112 Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2010-03-31
NCT00748007 Efficacy of Rivastigmine in Patients With Down Syndrome https://ClinicalTrials.gov/show/NCT00748007 Completed National Taiwan University Hospital 2009-12-31
NCT00689988 Augmentative and Alternative Communication (AAC) and Lexical Gain in Children With Down Syndrome https://ClinicalTrials.gov/show/NCT00689988 Completed University of Sao Paulo 2007-10-31
NCT00570128 Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In Treating Cognitive Dysfunction Exhibited By Children With Down Syndrome https://ClinicalTrials.gov/show/NCT00570128 Completed Eisai Inc. 2008-09-30
NCT00394290 Down Syndrome and Continuous Positive Pressure Therapy https://ClinicalTrials.gov/show/NCT00394290 Completed Institut Jerome Lejeune 2012-10-31
NCT00378456 Vitamins and Minerals for Children With Downs Syndrome https://ClinicalTrials.gov/show/NCT00378456 Completed Institute of Child Health NA
NCT00294593 Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome https://ClinicalTrials.gov/show/NCT00294593 Completed Institut Jerome Lejeune NA
NCT00003593 Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome https://ClinicalTrials.gov/show/NCT00003593 Completed Children’s Oncology Group 2007-03-31

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT04278404 Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) https://ClinicalTrials.gov/show/NCT04278404 Recruiting Duke University 2024-04-24
NCT03375359 First Trimester Screening for Trisomy 21, 18, 13 and 22q11.2 Deletion Syndrome https://ClinicalTrials.gov/show/NCT03375359 Recruiting University Hospital Tuebingen 2020-12-31
NCT03087357 VAlidation of a Lower Cost aneUploidy scrEen https://ClinicalTrials.gov/show/NCT03087357 Active, not recruiting Women and Infants Hospital of Rhode Island 2020-06-01
NCT02864108 The Crnic Institute Human Trisome Project Biobank https://ClinicalTrials.gov/show/NCT02864108 Recruiting University of Colorado, Denver 2036-07-31
NCT02859389 Neurocognitive and Psychosocial Outcomes in Survivors of Childhood Leukemia With Down Syndrome https://ClinicalTrials.gov/show/NCT02859389 Completed St. Jude Children’s Research Hospital 2019-01-31
NCT02787486 Expanded Noninvasive Genomic Medical Assessment: The Enigma Study https://ClinicalTrials.gov/show/NCT02787486 Completed Progenity, Inc. 2018-09-30
NCT02639312 Natural History of Craniofacial Anomalies and Developmental Growth Variants https://ClinicalTrials.gov/show/NCT02639312 Recruiting National Institutes of Health Clinical Center (CC) 2036-04-18
NCT02451657 Non-drug Study to Evaluate the Suitability of Neurocognitive Tests and Functioning Scales for the Measurement of Cognitive and Functioning Changes in Children With Down Syndrome https://ClinicalTrials.gov/show/NCT02451657 Completed Hoffmann-La Roche 2016-06-30
NCT02443597 Can Increased Body Mass Index Prevent Adequate Ultrasound Examination for Trisomy 21 Risk Assessment? https://ClinicalTrials.gov/show/NCT02443597 Completed Benha University 2015-12-31
NCT02431117 Non-drug Study to Assess the Suitability of Assessment Scales in Japanese Individuals With Down Syndrome Aged 6-30 https://ClinicalTrials.gov/show/NCT02431117 Completed Chugai Pharmaceutical 2016-07-31
NCT02430584 Whole Blood Specimen Collection From Pregnant Subjects https://ClinicalTrials.gov/show/NCT02430584 Active, not recruiting Progenity, Inc. 2020-03-31
NCT02317965 Non-Invasive Screening for Fetal Aneuploidy https://ClinicalTrials.gov/show/NCT02317965 Active, not recruiting Progenity, Inc. 2018-11-30
NCT02288702 Comparison of Bispectral Index Values in Patients With and Without Down’s Syndrome https://ClinicalTrials.gov/show/NCT02288702 Recruiting Milton S. Hershey Medical Center 2021-02-28
NCT02278874 High Risk Multiple Gestation Study https://ClinicalTrials.gov/show/NCT02278874 Completed Natera, Inc. 2018-12-01
NCT02278536 Multiple Gestation Study https://ClinicalTrials.gov/show/NCT02278536 Completed Natera, Inc. 2019-03-31
NCT02201862 Non-Invasive Chromosomal Evaluation of Trisomy Study https://ClinicalTrials.gov/show/NCT02201862 Completed Roche Sequencing Solutions 2019-08-01
NCT02141971 Down Syndrome Biomarker Initiative (DSBI) https://ClinicalTrials.gov/show/NCT02141971 Completed University of California, San Diego 2017-04-15
NCT02109770 Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA https://ClinicalTrials.gov/show/NCT02109770 Completed Natera, Inc. 2019-06-30
NCT01303133 Natural History of Amyloid Deposition in Adults With Down Syndrome https://ClinicalTrials.gov/show/NCT01303133 Completed University of Pittsburgh 2018-03-31
NCT01966991 Prenatal Screening for Down Syndrome With DNAFirst https://ClinicalTrials.gov/show/NCT01966991 Completed Women and Infants Hospital of Rhode Island 2015-07-31
NCT01950624 DS-Connect {TM}: The Down Syndrome Registry https://ClinicalTrials.gov/show/NCT01950624 Recruiting National Institutes of Health Clinical Center (CC) 2024-05-26
NCT01931644 At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions https://ClinicalTrials.gov/show/NCT01931644 Recruiting Sanguine Biosciences 2025-08-31
NCT01920633 A Screening Protocol to Assess Adults and Adolescents With Down Syndrome for Eligibility For Upcoming Study of RG1662 (Study BP27832) https://ClinicalTrials.gov/show/NCT01920633 Completed Hoffmann-La Roche 2015-01-31
NCT01902407 Computer Models of Airways in Children and Young Adults With Sleep Apnea and Down Syndrome https://ClinicalTrials.gov/show/NCT01902407 Enrolling by invitation Children’s Hospital Medical Center, Cincinnati 2027-12-31
NCT01852708 Development of Non-invasive Prenatal Screening Test for Microdeletions Based on Fetal DNA Isolated From Maternal Blood https://ClinicalTrials.gov/show/NCT01852708 Recruiting Natera, Inc. 2020-11-30
NCT01821300 Down Syndrome Metabolic Health Study https://ClinicalTrials.gov/show/NCT01821300 Completed Children’s Hospital of Philadelphia 2017-08-25
NCT01663675 Trisomy 21 in Adulthood https://ClinicalTrials.gov/show/NCT01663675 Recruiting University Hospital, Strasbourg, France 2019-10-31
NCT01663350 Comparison of Aneuploidy Risk Evaluations https://ClinicalTrials.gov/show/NCT01663350 Completed Verinata Health, Inc. 2013-07-31
NCT01597063 Clinical Evaluation of the SEQureDx Trisomy Test in Low Risk Pregnancies https://ClinicalTrials.gov/show/NCT01597063 Completed Sequenom, Inc. 2014-02-28
NCT01580384 A Non-Drug Study of The Suitability of Neurocognitive Tests And Functioning Scales For The Measurement of Cognitive And Functioning Changes in Individuals With Down Syndrome https://ClinicalTrials.gov/show/NCT01580384 Completed Hoffmann-La Roche 2014-01-31
NCT01555346 Clinical Evaluation of the SEQureDx T21 Test In High Risk Pregnancies https://ClinicalTrials.gov/show/NCT01555346 Completed Sequenom, Inc. 2014-10-31
NCT01545674 Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial https://ClinicalTrials.gov/show/NCT01545674 Active, not recruiting Natera, Inc. 2014-04-30
NCT01511575 Studying Biomarker Expression in Samples From Patients With Down Syndrome and Acute Myeloid Leukemia or Other Transient Myeloproliferative Disorder https://ClinicalTrials.gov/show/NCT01511575 Completed Children’s Oncology Group 2016-05-31
NCT01511458 Non-invasive Chromosomal Examination of Trisomy Study https://ClinicalTrials.gov/show/NCT01511458 Completed Roche Sequencing Solutions 2013-11-30
NCT01507441 Studying DNA in Samples From Younger Patients With Down Syndrome and Acute Myeloid Leukemia Treated on COG-AAML0431 Clinical Trial https://ClinicalTrials.gov/show/NCT01507441 Completed Children’s Oncology Group 2016-05-31
NCT01429389 Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy https://ClinicalTrials.gov/show/NCT01429389 Recruiting Sequenom, Inc. 2022-12-31
NCT01390558 Gait Parameters of Persons With Down Syndrome With and Without Orthotics Using GaitRite https://ClinicalTrials.gov/show/NCT01390558 Completed Oregon Health and Science University 2018-08-27
NCT04241042 Clinical Validation of the Bordeaux Maze Test https://ClinicalTrials.gov/show/NCT04241042 Recruiting Parc de Salut Mar 2020-04-30
NCT04208685 Evaluating Cognitive Outcomes in Down Syndrome https://ClinicalTrials.gov/show/NCT04208685 Recruiting Children’s Hospital Medical Center, Cincinnati 2023-06-30
NCT04149197 Down Syndrome Clinical Trials - Study of Alzheimer’s Disease in Down Syndrome https://ClinicalTrials.gov/show/NCT04149197 Recruiting LuMind IDSC Foundation 2022-03-30
NCT04035967 Investigation of Parents’ Anxiety Level and Health Related Quality of Life in Different Types of Physical Disabilities https://ClinicalTrials.gov/show/NCT04035967 Completed Sanko University 2019-05-01
NCT03942341 Sleep in Adults With Down Syndrome and Alzheimer’s Disease https://ClinicalTrials.gov/show/NCT03942341 Recruiting Fundació Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau 2020-03-31
NCT03922165 Healthy Sleep for Children With Down Syndrome https://ClinicalTrials.gov/show/NCT03922165 Recruiting Brigham and Women’s Hospital 2020-07-01
NCT02941887 Global Behavior and Periodontal Disease in Down’s Syndrome Patients https://ClinicalTrials.gov/show/NCT02941887 Completed University of Sao Paulo 2016-10-31
NCT03635359 Automated Screen for Fetal Aneuploidy https://ClinicalTrials.gov/show/NCT03635359 Enrolling by invitation BioCeryx 2019-03-31
NCT03629795 Serum Sample Collection to Determine Analytical Performance Characteristics of the ADVIA Centaur PAPPA and BhCG Assays https://ClinicalTrials.gov/show/NCT03629795 Completed Axis Shield Diagnostics Ltd 2018-01-24
NCT03602378 QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease https://ClinicalTrials.gov/show/NCT03602378 Enrolling by invitation University of Split, School of Medicine 2021-04-02
NCT03559374 Study of Vanadis® NIPT for Non-invasive Prenatal Screening of Trisomies (T21, T18 and T13) https://ClinicalTrials.gov/show/NCT03559374 Enrolling by invitation PerkinElmer, Wallac Oy 2020-04-30
NCT03553706 Indicators of Growth, Nutritional Status and Comorbide Disorders of Newborns With Down Syndrome https://ClinicalTrials.gov/show/NCT03553706 Completed University Hospital of Split 2018-05-30
NCT03445962 19/5000 (SYNAPSOT21) Predictive Factors of Sleep Apnea Syndrome in Down Syndrome https://ClinicalTrials.gov/show/NCT03445962 Active, not recruiting University Hospital, Grenoble 2019-12-31
NCT01118507 Trisomy of Chromosome 21 Diagnosis by High Output Sequencing https://ClinicalTrials.gov/show/NCT01118507 Completed Assistance Publique - Hôpitaux de Paris 2013-09-30
NCT01052688 Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies https://ClinicalTrials.gov/show/NCT01052688 Recruiting Sequenom, Inc. 2021-06-30
NCT01041469 Pilot Study of Auto-immune Abnormalities Associated With Down Syndrome https://ClinicalTrials.gov/show/NCT01041469 Completed Institut Jerome Lejeune NA
NCT01034280 Correlations Phenotype / Genotype in Down Syndrome https://ClinicalTrials.gov/show/NCT01034280 Completed Institut Jerome Lejeune NA
NCT00971334 Noninvasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker https://ClinicalTrials.gov/show/NCT00971334 Completed Sequenom, Inc. 2011-09-30
NCT00959283 Study of Blood Samples From Newborns With Down Syndrome https://ClinicalTrials.gov/show/NCT00959283 Active, not recruiting Children’s Oncology Group 2011-12-30
NCT00951730 Evaluation of a Simplified Method for Diagnosis of Sleep Apnea in Children and Adults With Down Syndrome https://ClinicalTrials.gov/show/NCT00951730 Completed Centre Hospitalier Universitaire de Saint Etienne 2015-02-28
NCT00879515 Examining Social, Emotional, and Cognitive Functioning in People With Fragile X and Down Syndromes https://ClinicalTrials.gov/show/NCT00879515 Completed University of California, Davis 2010-09-30
NCT00877292 A New Prenatal Blood Test for Down Syndrome https://ClinicalTrials.gov/show/NCT00877292 Completed Women and Infants Hospital of Rhode Island 2011-01-31
NCT00864461 Frequency of Metabolic Syndrome in Down Syndrome Patients https://ClinicalTrials.gov/show/NCT00864461 Completed Universidad de Guanajuato 2009-12-21
NCT00847990 Non-Invasive Screening for Fetal Aneuploidy https://ClinicalTrials.gov/show/NCT00847990 Completed Sequenom, Inc. 2011-04-30
NCT00844259 Functional Communicative Profile of Children With Down Syndrome https://ClinicalTrials.gov/show/NCT00844259 Completed University of Sao Paulo 2007-10-31
NCT01256606 Prenatal Test for Fetal Aneuploidy Detection https://ClinicalTrials.gov/show/NCT01256606 Completed Roche Sequencing Solutions 2011-11-30
NCT00770458 Non-Invasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker https://ClinicalTrials.gov/show/NCT00770458 Completed Sequenom, Inc. 2009-10-31
NCT00668980 Symbolic Representation in Young Children With Down Syndrome https://ClinicalTrials.gov/show/NCT00668980 Completed University of Sao Paulo 2009-04-30
NCT00643552 Muscle Strength, Physical Work Capacity and Functional Performance in Individuals With Down Syndrome https://ClinicalTrials.gov/show/NCT00643552 Completed State University of New York - Upstate Medical University NA
NCT00478296 Pulmonary Hypertension in Trisomy 21 Patients https://ClinicalTrials.gov/show/NCT00478296 Completed Children’s Healthcare of Atlanta 2007-02-28
NCT00287417 Early Ultrasound and Maternal Biochemical Markers to Evaluate the Risk of Down Syndrome During the First Trimester https://ClinicalTrials.gov/show/NCT00287417 Completed University Hospital, Strasbourg, France NA
NCT00695695 The Experience of Caregivers of Children With Down Syndrome https://ClinicalTrials.gov/show/NCT00695695 Completed National Institutes of Health Clinical Center (CC) NA
NCT00005190 Reproduction and Survival After Cardiac Defect Repair https://ClinicalTrials.gov/show/NCT00005190 Completed National Heart, Lung, and Blood Institute (NHLBI) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02612376 Rocky Mountain Alzheimer’s Disease Center Longitudinal Biomarker and Clinical Phenotyping Study https://ClinicalTrials.gov/show/NCT02612376 Recruiting University of Colorado, Denver 2030-12-31
NCT02381457 SNP-based Microdeletion and Aneuploidy RegisTry (SMART) https://ClinicalTrials.gov/show/NCT02381457 Active, not recruiting Natera, Inc. 2020-04-30